Brain Sciences

 

Brain Sci., Volume 11, Issue 1 (January 2021) – 127 articles

Cover Story (view full-size image): Multiple sclerosis (MS) is a neurodegenerative disease that causes lesion formation and tissue loss or atrophy in the brain. Cognitive and motor challenges are commonly observed in people with MS. Reduced speed of information processing is typically the first sign of cognitive involvement, which in turn broadly affects other cognitive processes including attention, executive function, and memory. The Attention Network Test—Interactions can measure the efficiency of 3 distinct attentional processes—alerting, orienting, and executive control. In this study, we measured attentional efficiencies and gray matter morphometry in a sample of young adults (18–35 years) with relatively mild MS severity. We show that thickness and volume changes in specific gray matter regions correlate with attentional efficiency even in the absence of widespread atrophy. View this paper

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Brain Sci., Volume 11, Issue 2 (February 2021) – 153 articles

Cover Story (view full-size image): Exosomes comprise a significant class of microvesicular bodies synthesized and secreted by different cell types in many tissues, including brain. Biomolecular cargo in exosomes consist of proteins, lipids, metabolites and microRNAs that reflect the physiological status of the cell-of-origin. The role of exosomes in pathogenesis and disease progression of neurodegenerative disorders is evident from their ability to transport pathogenetic proteins and to communicate signals between different brain cell types. The high sensitivity and specificity of MS/proteomics provides a valuable tool for identifying exosomal biomarker candidates. This review highlights advancements in exosome proteomics and its potential for identifying protein biomarkers for neurodegenerative and neuropsychiatric disorders. “Image created with BioRender.com”. View this paper

 

• Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
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• PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

• Brain Sci., Volume 11, Issue 3 (March 2021) – 128 articles

  
  Cover Story (view full-size image): Stroke induces a loss in neurovascular coupling and an increase in reactive astrogliosis while producing abnormal conditions of excitability and plasticity in brain regions surrounding the infarct, which underlies the lasting disabilities observed in stroke patients. Drugs that block tonic GABA signalling promote neuronal excitability, enhance LTP formation, and lead to long-lasting enhancements in learning. Herein, GABAc receptors, which are found on astrocytes, were assessed as novel pharmacological targets for stroke recovery. Dampening GABAc receptor-mediated GABA signalling in astrocytes results in dampened reactive astrogliosis, improved astrocytic GABA uptake, and a lasting improvement in functional recovery. Image created using BioRender.com. View this paper
• Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
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• PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
• FOLLOW THIS LINK : https://www.mdpi.com/journal/brainsci